RAF1 KINASE INHIBITOR I
GW5074
CAS: 220904-83-6
Molecular Formula: C15H8Br2INO2
RAF1 KINASE INHIBITOR I - Names and Identifiers
RAF1 KINASE INHIBITOR I - Physico-chemical Properties
| Molecular Formula | C15H8Br2INO2 |
| Molar Mass | 520.94 |
| Density | 2.248±0.06 g/cm3(Predicted) |
| Boling Point | 561.4±50.0 °C(Predicted) |
| Solubility | DMSO: soluble |
| Appearance | solid |
| Color | yellow to orange-brown |
| pKa | 5.86±0.25(Predicted) |
| Storage Condition | room temp |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| MDL | MFCD03453076 |
| Use | GW5074 |
| In vitro study | GW5074 is a potent, specific c-Raf inhibitor with an IC50 of 9 nM and has no inhibitory activity against MEK6, MKK7, p38 MAP kinase and cdks in vitro. However, treatment of the neuronal medium with GW5074 accumulated c-Raf and B- Raf of the activation modification. GW5074 inhibits LK-induced apoptosis in cerebellar granule neurons in a MEK-ERK independent manner. GW5074 delays down-regulation of Akt activity, but inhibits apoptosis through an Akt-independent mechanism. GW5074 affects Ras, NF-kappa B and c-jun. GW5074 acts on granulosa cells and other neuronal types to inhibit cell death caused by neurotoxins. GW5074 is a potent, specific c-Raf inhibitor with an IC50 of 9 nM and no inhibitory activity against MEK6, MKK7, p38 MAP kinase and cdks in vitro. However, treatment of the neuronal medium with GW5074 accumulated c-Raf and B- Raf of the activation modification. GW5074 inhibits LK-induced apoptosis in cerebellar granule neurons in a MEK-ERK independent manner. GW5074 delays down-regulation of Akt activity, but inhibits apoptosis through an Akt-independent mechanism. GW5074 affects Ras, NF-kappa B and c-jun. GW5074 acts on granulosa cells and other neuronal types to inhibit cell death caused by neurotoxins. |
| In vivo study | GW5074 protects an in vivo experimental model of Huntington's disease. Treatment of mice with GW5074(5 mg/kg) completely inhibited 3-NP-induced bilateral striatal lesions. GW5074 acts on CHO cells stably expressing human opioid receptors, completely abrogating chronic morphine-mediated AC hyperactivation I. GW5074 treated mice inhibited lateral flow smoke induced airway hyperresponsiveness. GW5074 protects an in vivo experimental model of Huntington's disease. Treatment of mice with GW5074(5 mg/kg) completely inhibited 3-NP-induced bilateral striatal lesions. GW5074 acts on CHO cells stably expressing human opioid receptors, completely abrogating chronic morphine-mediated AC hyperactivation I. GW5074 treated mice inhibited lateral flow smoke induced airway hyperresponsiveness. |
RAF1 KINASE INHIBITOR I - Risk and Safety
| WGK Germany | 3 |
RAF1 KINASE INHIBITOR I - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.92 ml | 9.598 ml | 19.196 ml |
| 5 mM | 0.384 ml | 1.92 ml | 3.839 ml |
| 10 mM | 0.192 ml | 0.96 ml | 1.92 ml |
| 5 mM | 0.038 ml | 0.192 ml | 0.384 ml |
Last Update：2024-01-02 23:10:35
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Featured ProductsSpot supply
Product Name: GW5074 Visit Supplier Webpage Request for quotationCAS: 220904-83-6
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: GW 5074 Visit Supplier Webpage Request for quotationCAS: 220904-83-6
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: GW5074 Visit Supplier Webpage Request for quotationCAS: 220904-83-6
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: GW5074 Visit Supplier Webpage Request for quotationCAS: 220904-83-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
RAF1 KINASE INHIBITOR I
BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID
Valeric acid 1-methylethyl ester
6-TAMRA 6羧基四甲基罗丹明马来酰亚胺
3β.6β-Dihydroxy-Δ4-cholansaeure
PALMITIC ACID OLEYL ESTER
2-氨基-3-氟异烟腈
ALPHA-溴-4-硝基-O-甲酚
2-isocyanato-1,3-bis[[2-isocyanato-3-[(2-isocyanatophenyl) methyl] phenyl] methyl]-Benzene
GIBBERELLIC ACID A4
BUTOXYCARBONYLAMINO-CYCLOPROPYL-ACETIC ACID
Valeric acid 1-methylethyl ester
6-TAMRA 6羧基四甲基罗丹明马来酰亚胺
3β.6β-Dihydroxy-Δ4-cholansaeure
PALMITIC ACID OLEYL ESTER
2-氨基-3-氟异烟腈
ALPHA-溴-4-硝基-O-甲酚
2-isocyanato-1,3-bis[[2-isocyanato-3-[(2-isocyanatophenyl) methyl] phenyl] methyl]-Benzene
GIBBERELLIC ACID A4